Combine all dry rub ingredients in a small bowl. Stir thoroughly until the seasonings are evenly distributed and there are no visible clumps, especially from the garlic powder and paprika.
Sprinkle the dry rub generously over your meat, coating all sides. You may not need to use the entire batch—the amount depends on the size and type of meat you are seasoning. Press the rub in lightly so it adheres well.
Allow to marinate for at least 4 hours, preferably overnight. For best flavor, keep the meat covered and chilled while it rests, then let it sit briefly at room temperature before cooking if appropriate for your recipe.